Henipavirus Encephalitis: Recent Developments and Advances
Identifieur interne : 001460 ( Main/Exploration ); précédent : 001459; suivant : 001461Henipavirus Encephalitis: Recent Developments and Advances
Auteurs : Kien Chai Ong [Malaisie] ; Kum Thong Wong [Malaisie]Source :
- Brain Pathology [ 1015-6305 ] ; 2015-09.
Abstract
The genus Henipavirus within the family Paramyxoviridae includes the Hendra virus (HeV) and Nipah virus (NiV) which were discovered in the 1990s in Australia and Malaysia, respectively, after emerging to cause severe and often fatal outbreaks in humans and animals. While HeV is confined to Australia, more recent NiV outbreaks have been reported in Bangladesh, India and the Philippines. The clinical manifestations of both henipaviruses in humans appear similar, with a predominance of an acute encephalitic syndrome. Likewise, the pathological features are similar and characterized by disseminated, multi‐organ vasculopathy comprising endothelial infection/ulceration, vasculitis, vasculitis‐induced thrombosis/occlusion, parenchymal ischemia/microinfarction, and parenchymal cell infection in the central nervous system (CNS), lung, kidney and other major organs. This unique dual pathogenetic mechanism of vasculitis‐induced microinfarction and neuronal infection causes severe tissue damage in the CNS. Both viruses can also cause relapsing encephalitis months and years after the acute infection. Many animal models studied to date have largely confirmed the pathology of henipavirus infection, and provided the means to test new therapeutic agents and vaccines. As the bat is the natural host of henipaviruses and has worldwide distribution, spillover events into human populations are expected to occur in the future.
Url:
DOI: 10.1111/bpa.12278
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001838
- to stream Istex, to step Curation: 001838
- to stream Istex, to step Checkpoint: 000171
- to stream Main, to step Merge: 001462
- to stream Main, to step Curation: 001460
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Henipavirus Encephalitis: Recent Developments and Advances</title>
<author><name sortKey="Ong, Kien Chai" sort="Ong, Kien Chai" uniqKey="Ong K" first="Kien Chai" last="Ong">Kien Chai Ong</name>
</author>
<author><name sortKey="Wong, Kum Thong" sort="Wong, Kum Thong" uniqKey="Wong K" first="Kum Thong" last="Wong">Kum Thong Wong</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:DDAE120273802D9A53863EEE25AECA90DA0B017F</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1111/bpa.12278</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-D0WSD0PP-J/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001838</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001838</idno>
<idno type="wicri:Area/Istex/Curation">001838</idno>
<idno type="wicri:Area/Istex/Checkpoint">000171</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000171</idno>
<idno type="wicri:doubleKey">1015-6305:2015:Ong K:henipavirus:encephalitis:recent</idno>
<idno type="wicri:Area/Main/Merge">001462</idno>
<idno type="wicri:Area/Main/Curation">001460</idno>
<idno type="wicri:Area/Main/Exploration">001460</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Henipavirus Encephalitis: Recent Developments and Advances</title>
<author><name sortKey="Ong, Kien Chai" sort="Ong, Kien Chai" uniqKey="Ong K" first="Kien Chai" last="Ong">Kien Chai Ong</name>
<affiliation wicri:level="1"><country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Kum Thong" sort="Wong, Kum Thong" uniqKey="Wong K" first="Kum Thong" last="Wong">Kum Thong Wong</name>
<affiliation wicri:level="1"><country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department ofPathology, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Malaisie</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Brain Pathology</title>
<title level="j" type="alt">BRAIN PATHOLOGY</title>
<idno type="ISSN">1015-6305</idno>
<idno type="eISSN">1750-3639</idno>
<imprint><biblScope unit="vol">25</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="605">605</biblScope>
<biblScope unit="page" to="613">613</biblScope>
<biblScope unit="page-count">9</biblScope>
<date type="published" when="2015-09">2015-09</date>
</imprint>
<idno type="ISSN">1015-6305</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1015-6305</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">The genus Henipavirus within the family Paramyxoviridae includes the Hendra virus (HeV) and Nipah virus (NiV) which were discovered in the 1990s in Australia and Malaysia, respectively, after emerging to cause severe and often fatal outbreaks in humans and animals. While HeV is confined to Australia, more recent NiV outbreaks have been reported in Bangladesh, India and the Philippines. The clinical manifestations of both henipaviruses in humans appear similar, with a predominance of an acute encephalitic syndrome. Likewise, the pathological features are similar and characterized by disseminated, multi‐organ vasculopathy comprising endothelial infection/ulceration, vasculitis, vasculitis‐induced thrombosis/occlusion, parenchymal ischemia/microinfarction, and parenchymal cell infection in the central nervous system (CNS), lung, kidney and other major organs. This unique dual pathogenetic mechanism of vasculitis‐induced microinfarction and neuronal infection causes severe tissue damage in the CNS. Both viruses can also cause relapsing encephalitis months and years after the acute infection. Many animal models studied to date have largely confirmed the pathology of henipavirus infection, and provided the means to test new therapeutic agents and vaccines. As the bat is the natural host of henipaviruses and has worldwide distribution, spillover events into human populations are expected to occur in the future.</div>
</front>
</TEI>
<affiliations><list><country><li>Malaisie</li>
</country>
</list>
<tree><country name="Malaisie"><noRegion><name sortKey="Ong, Kien Chai" sort="Ong, Kien Chai" uniqKey="Ong K" first="Kien Chai" last="Ong">Kien Chai Ong</name>
</noRegion>
<name sortKey="Wong, Kum Thong" sort="Wong, Kum Thong" uniqKey="Wong K" first="Kum Thong" last="Wong">Kum Thong Wong</name>
<name sortKey="Wong, Kum Thong" sort="Wong, Kum Thong" uniqKey="Wong K" first="Kum Thong" last="Wong">Kum Thong Wong</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001460 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001460 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:DDAE120273802D9A53863EEE25AECA90DA0B017F |texte= Henipavirus Encephalitis: Recent Developments and Advances }}
This area was generated with Dilib version V0.6.33. |